Diagnosis of Endometrial-Factor Infertility: Current Approaches and New Avenues for Research.

ABSTRACT: Over the last decade, research to improve success rates in reproductive medicine has focused predominantly on the understanding and optimization of embryo quality. However, the emergence of personalized medicine in ovulation induction and embryology has shifted the focus to assessing the individual status of the endometrium. The endometrium is considered receptive during an individually defined period, the window of implantation (WOI), when the mother permits a blastocyst to attach and implant. This individual receptivity status can now be objectively diagnosed using the endometrial receptivity array (ERA) developed in 2011. The ERA, together with a computational algorithm, detects the unique transcriptomic signature of endometrial receptivity by analyzing 238 differentially expressed gene

SUBMITTER: Katzorke N 

PROVIDER: S-EPMC4922892 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature