Calreticulin (CALR) mutation in myeloproliferative neoplasms (MPNs).

ABSTRACT: As a heterogeneous group of disease, myeloproliferative neoplasms (MPNs) have confused hematologists and hematopathologists with their protean clinical presentations and myriads of morphologies. A thought of classifying MPNs based on molecular alterations has gained popularity because there is increasing evidence that molecular or chromosomal alterations have a better correlation with clinical presentation, response to therapies, and prognosis than conventional morphological classification. This type of efforts has been facilitated by the advancement of molecular technologies. A significant number of gene mutations have been identified in MPNs with JAK2 and MPL being the major ones. However, a significant gap is present in that many cases of MPNs do not harbor any of these mutations. This

SUBMITTER: Luo W 

PROVIDER: S-EPMC4923638 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature