Three-dimensional registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation.

ABSTRACT: Evidence suggests high-resolution, high-contrast, [Formula: see text] intravascular optical coherence tomography (IVOCT) can distinguish plaque types, but further validation is needed, especially for automated plaque characterization. We developed experimental and three-dimensional (3-D) registration methods to provide validation of IVOCT pullback volumes using microscopic, color, and fluorescent cryo-image volumes with optional registered cryo-histology. A specialized registration method matched IVOCT pullback images acquired in the catheter reference frame to a true 3-D cryo-image volume. Briefly, an 11-parameter registration model including a polynomial virtual catheter was initialized within the cryo-image volume, and perpendicular images were extracted, mimicking IVOCT image acquisiti

SUBMITTER: Prabhu D 

PROVIDER: S-EPMC4923671 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature