Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology.

ABSTRACT:

Background

Four previously reported studies have tested for association of blood proteins with neocortical amyloid-β burden (NAB). If shown to be robust, these proteins could have utility as a blood test for enrichment in clinical trials of Alzheimer's disease (AD) therapeutics.

Objective

This study aimed to investigate whether previously identified blood proteins also show evidence for association with NAB in serum samples from the Australian Imaging, Biomarker and Lifestyle Flagship Study of Ageing (AIBL). The study considers candidate proteins seen in cohorts other than AIBL and candidates previously discovered in the AIBL cohort.

Methods

Our study used the SOMAscan platform for protein quantification in blood serum. Linear and logistic regressions were used to mod

SUBMITTER: Voyle N 

PROVIDER: S-EPMC4923714 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature