APOE-ɛ4 Carrier Status and Donepezil Response in Patients with Alzheimer's Disease.

ABSTRACT:

Background

Previous studies have investigated associations between apolipoprotein E (APOE)-ɛ4 allele status and acetylcholinesterase inhibitor treatment response in patients with Alzheimer's disease. The ability to draw definitive conclusions regarding the effect of APOE-ɛ4 genotype on treatment response has been hindered by inconsistent results among studies and methodological limitations that restrict interpretation of study findings.

Objective

To determine whether APOE-ɛ4 carrier status influences the magnitude of change in 13-item Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) score associated with acetylcholinesterase inhibitor treatment (i.e., donepezil).

Methods

Analyses were performed using pooled data from the donepezil and placebo treatme

SUBMITTER: Waring JF 

PROVIDER: S-EPMC4923746 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature