Changes in cerebral metabolites in obstructive sleep apnea: a systemic review and meta-analysis.

ABSTRACT: Cognitive impairment is associated with changes in cerebral metabolites in patients with obstructive sleep apnea (OSA). Several studies have used magnetic resonance spectroscopy (MRS) to detect variations in cerebral metabolites; however, the results have been inconsistent. This meta-analysis summarizes the differences in cerebral metabolites between patients with OSA and controls. Two electronic databases, PubMed and Embase, were searched for articles (published before March 31, 2016) describing studies that used MRS to evaluate the cerebral metabolite changes. The overall effects were measured using the weighted mean difference with a 95% confidence interval. Subgroup analysis and sensitivity analysis were used to explore the sources of between-study heterogeneity and the stability of th

SUBMITTER: Xia Y 

PROVIDER: S-EPMC4923864 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature