Plasma proteomic analysis of stable coronary artery disease indicates impairment of reverse cholesterol pathway.

ABSTRACT: Coronary artery disease (CAD) is one of the largest causes of death worldwide yet the traditional risk factors, although useful in identifying people at high risk, lack the desired predictive accuracy. Techniques like quantitative plasma proteomics holds immense potential to identify newer markers and this study (conducted in three phases) was aimed to identify differentially expressed proteins in stable CAD patients. In the first (discovery) phase, plasma from CAD cases (angiographically proven) and controls were subjected to iTRAQ based proteomic analysis. Proteins found to be differentially expressed were then validated in the second and third (verification and validation) phases in larger number of (n = 546) samples. After multivariate logistic regression adjusting for confounding fact

SUBMITTER: Basak T 

PROVIDER: S-EPMC4923873 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature