Genome wide analysis of protein production load in Trichoderma reesei.

ABSTRACT:

Background

The filamentous fungus Trichoderma reesei (teleomorph Hypocrea jecorina) is a widely used industrial host organism for protein production. In industrial cultivations, it can produce over 100 g/l of extracellular protein, mostly constituting of cellulases and hemicellulases. In order to improve protein production of T. reesei the transcriptional regulation of cellulases and secretory pathway factors have been extensively studied. However, the metabolism of T. reesei under protein production conditions has not received much attention.

Results

To understand the physiology and metabolism of T. reesei under protein production conditions we carried out a well-controlled bioreactor experiment with extensive analysis. We used minimal media to make the data amenable for mo

SUBMITTER: Pakula TM 

PROVIDER: S-EPMC4924338 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature