Retrospective study testing next generation sequencing of selected cancer-associated genes in resected prostate cancer.

ABSTRACT:

Purpose

Prostate cancer (PCa) has a highly heterogeneous outcome. Beyond Gleason Score, Prostate Serum Antigen and tumor stage, nowadays there are no biological prognostic factors to discriminate between indolent and aggressive tumors.The most common known genomic alterations are the TMPRSS-ETS translocation and mutations in the PI3K, MAPK pathways and in p53, RB and c-MYC genes.The aim of this retrospective study was to identify by next generation sequencing the most frequent genetic variations (GVs) in localized and locally advanced PCa underwent prostatectomy and to investigate their correlation with clinical-pathological variables and disease progression.

Results

Identified non-synonymous GVs included TP53 p.P72R (78% of tumors), two CSFR1 SNPs, rs2066934 and rs2066933 (

SUBMITTER: Lo Iacono M 

PROVIDER: S-EPMC4924723 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature