The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer.

ABSTRACT:

Background & aims

Breast cancer (BC) is prevalent worldwide malignant cancer. Improvements in timely and effective diagnosis and prediction are needed. As reported, secreted DAND5 is contributed to BC metastasis. We aim to assess whether DAND5 in peripheral blood serum could determine BC-specific mortality.

Methods

We used immunohistochemistry staining to detect DAND5 expression in our BC tissue array including 250 samples. Angiogenesis assay and xenograft mice model were used to examine the secreted DAND5 function in BC progression. Serum concentration of DAND5 was examined by ELISA in 1730 BC patients. Kaplan-Meier and adjusted Cox proportional hazards models were utilized to analyze the prognosis and survival of BC patients.

Results

Tissue array results showed that

SUBMITTER: Chi Y 

PROVIDER: S-EPMC4924764 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature