Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression.

ABSTRACT: Melanoma is notorious for its high tendency to metastasize and its refractoriness to conventional treatments after metastasis, and the responses to most targeted therapies are short-lived. A better understanding of the molecular mechanisms behind melanoma development and progression is needed to develop more effective therapies and to identify new markers to predict disease behavior. Here, we compared the gene expression profiles of benign nevi, and non-metastatic and metastatic primary melanomas to identify any common changes in disease progression. We identified several genes associated with inflammation, angiogenesis, and extracellular matrix modification to be upregulated in metastatic melanomas. We selected one of these genes, collagen triple helix repeat containing 1 (CTHRC1), for de

SUBMITTER: Eriksson J 

PROVIDER: S-EPMC4924771 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature