Cardiac myosin-Th17 responses promote heart failure in human myocarditis.

ABSTRACT: In human myocarditis and its sequela dilated cardiomyopathy (DCM), the mechanisms and immune phenotype governing disease and subsequent heart failure are not known. Here, we identified a Th17 cell immunophenotype of human myocarditis/DCM with elevated CD4⁺IL17⁺ T cells and Th17-promoting cytokines IL-6, TGF-β, and IL-23 as well as GM-CSF-secreting CD4⁺ T cells. The Th17 phenotype was linked with the effects of cardiac myosin on CD14⁺ monocytes, TLR2, and heart failure. Persistent heart failure was associated with high percentages of IL-17-producing T cells and IL-17-promoting cytokines, and the myocarditis/DCM phenotype included significantly low percentages of FOXP3⁺ Tregs, which may contribute to disease severity. We demonstra

SUBMITTER: Myers JM 

PROVIDER: S-EPMC4924810 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature