Metformin treatment status and abdominal aortic aneurysm disease progression.

ABSTRACT:

Objective

In population-based studies performed on multiple continents during the past two decades, diabetes mellitus has been negatively associated with the prevalence and progression of abdominal aortic aneurysm (AAA) disease. We investigated the possibility that metformin, the primary oral hypoglycemic agent in use worldwide, may influence the progression of AAA disease.

Methods

Preoperative AAA patients with diabetes were identified from an institutional database. After tabulation of individual cardiovascular and demographic risk factors and prescription drug regimens, odds ratios for categorical influences on annual AAA enlargement were calculated through nominal logistical regression. Experimental AAA modeling experiments were subsequently performed in normoglycemic mi

SUBMITTER: Fujimura N 

PROVIDER: S-EPMC4925242 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature