Improvements in glycemic control after gastric bypass occur despite persistent adipose tissue inflammation.

ABSTRACT:

Objective

Type 2 diabetes commonly goes into remission following Roux-en-Y gastric bypass (RYGB). As the mechanisms remain incompletely understood, a reduction in adipose tissue inflammation may contribute to these metabolic improvements. Therefore, whether RYGB reduces adipose tissue inflammation compared with equivalent weight loss from an intensive lifestyle intervention was investigated.

Methods

Sixteen people with obesity and type 2 diabetes were randomized to RYGB or lifestyle intervention. Fasting blood and subcutaneous abdominal adipose tissue were obtained before and after the loss of ∼7% of baseline weight. Adipose tissue inflammation was assessed by whole-tissue gene expression and flow cytometry-based quantification of tissue leukocytes.

Results

At 7% weig

SUBMITTER: Kratz M 

PROVIDER: S-EPMC4925247 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature