Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release.

ABSTRACT: Vaccines are a critical clinical tool in preventing illness and death due to infectious diseases and are regularly administered to children and adults across the globe. In order to obtain full protection from many vaccines, an individual needs to receive multiple doses over the course of months. However, vaccine administration in developing countries is limited by the difficulty in consistently delivering a second or third dose, and some vaccines, including the inactivated polio vaccine (IPV), must be injected more than once for efficacy. In addition, IPV does not remain stable over time at elevated temperatures, such as those it would encounter over time in the body if it were to be injected as a single-administration vaccine. In this manuscript, we describe microspheres composed of poly(

SUBMITTER: Tzeng SY 

PROVIDER: S-EPMC4925381 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature