Ectopic and Visceral Fat Deposition in Lean and Obese Patients With Type 2 Diabetes.

ABSTRACT:

Background

Type 2 diabetes (T2D) and obesity are associated with nonalcoholic fatty liver disease, cardiomyopathy, and cardiovascular mortality. Both show stronger links between ectopic and visceral fat deposition, and an increased cardiometabolic risk compared with subcutaneous fat.

Objectives

This study investigated whether lean patients (Ln) with T2D exhibit increased ectopic and visceral fat deposition and whether these are linked to cardiac and hepatic changes.

Methods

Twenty-seven obese patients (Ob) with T2D, 15 Ln-T2D, and 12 normal-weight control subjects were studied. Subjects underwent cardiac computed tomography, cardiac magnetic resonance imaging (MRI), proton and phosphorus MR spectroscopy, and multiparametric liver MR, including hepatic proton MRS, T1-

SUBMITTER: Levelt E 

PROVIDER: S-EPMC4925621 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature