Optimal HMPAO α value for Lassen's correction algorithm obscured by statistical noise.

ABSTRACT:

Objective

[(99m)Tc] D,L-hexamethyl-propyeneamine oxime ((99m)Tc-HMPAO), a brain perfusion tracer, suffers significant underestimation of regional cerebral blood flow (rCBF). Lassen et al. developed their linearization algorithm to correct the influence of back-diffusion of the tracer, and proposed their parameter α as 1.5. Based on mathematical modeling and literature review, recently, a new α value of 0.5 has been proposed for Lassen's correction algorithm for (99m)Tc-HMPAO, although correction using the old α value of 1.5 was confirmed to be sufficient. Inugami et al. reported that linearization correction gives a stable correlation coefficient over a wide range of α. Our hypotheses are that statistical noise is the source of the stable correlation coefficient presented by them a

SUBMITTER: Kameyama M 

PROVIDER: S-EPMC4925692 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature