Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin.

ABSTRACT: The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal-epidermal junction, a cell surface-associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perlecan, which are necessary for tissue organization and structural integrity. Perlecan is a heparan sulfate proteoglycan known to be involved in keratinocyte survival and differentiation. Aging affects the dermal epidermal junction resulting in decreased contact with keratinocytes, thus impacting epidermal renewal and homeostasis. We found that perlecan expression decreased during chronological skin aging. Our in vitro studies revealed reduced perlecan transcript levels in aged k

SUBMITTER: Dos Santos M 

PROVIDER: S-EPMC4925826 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature