The Sialidase NanS Enhances Non-TcsL Mediated Cytotoxicity of Clostridium sordellii.

ABSTRACT: The clostridia produce an arsenal of toxins to facilitate their survival within the host environment. TcsL is one of two major toxins produced by Clostridium sordellii, a human and animal pathogen, and is essential for disease pathogenesis of this bacterium. C. sordellii produces many other toxins, but the role that they play in disease is not known, although previous work has suggested that the sialidase enzyme NanS may be involved in the characteristic leukemoid reaction that occurs during severe disease. In this study we investigated the role of NanS in C. sordellii disease pathogenesis. We constructed a nanS mutant and showed that NanS is the only sialidase produced from C. sordellii strain ATCC9714 since sialidase activity could not be detected from the nanS mutant. Complementation wi

SUBMITTER: Awad MM 

PROVIDER: S-EPMC4926155 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature