Identification of Vimentin as a Potential Therapeutic Target against HIV Infection.

ABSTRACT: A combination of antiviral drugs known as antiretroviral therapy (ART) has shown effectiveness against the human immunodeficiency virus (HIV). ART has markedly decreased mortality and morbidity among HIV-infected patients, having even reduced HIV transmission. However, an important current disadvantage, resistance development, remains to be solved. Hope is focused on developing drugs against cellular targets. This strategy is expected to prevent the emergence of viral resistance. In this study, using a comparative proteomic approach in MT4 cells treated with an anti-HIV leukocyte extract, we identified vimentin, a molecule forming intermediate filaments in the cell, as a possible target against HIV infection. We demonstrated a strong reduction of an HIV-1 based lentivirus expressing the en

SUBMITTER: Fernandez-Ortega C 

PROVIDER: S-EPMC4926169 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature