Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA.

ABSTRACT: Truncated receptor ectodomains have been described for several classes of cell surface receptors, including those that bind to growth factors, cytokines, immunoglobulins, and adhesion molecules. Soluble receptor isoforms are typically generated by proteolytic cleavage of the cell surface receptor or by alternative splicing of RNA transcripts arising from the same gene encoding the full-length receptor. Both the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) families produce soluble receptor splice variants in vertebrates and truncated forms of insulin receptor-like sequences have previously been described in Drosophila. The EGFR and INSR ectodomains share significant sequence homology with each other suggestive of a common evolutionary origin. We discovered

SUBMITTER: Vastermark A 

PROVIDER: S-EPMC4926259 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature