Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.

ABSTRACT:

Background

Altered metabolism is a hallmark of cancer. However, the role of genomic changes in metabolic genes driving the tumour metabolic shift remains to be elucidated. Here, we have investigated the genomic and transcriptomic changes underlying this shift across ten different cancer types.

Results

A systematic pan-cancer analysis of 6538 tumour/normal samples covering ten major cancer types identified a core metabolic signature of 44 genes that exhibit high frequency somatic copy number gains/amplifications (>20 % cases) associated with increased mRNA expression (ρ > 0.3, q < 10(-3)). Prognostic classifiers using these genes were confirmed in independent datasets for breast and kidney cancers. Interestingly, this signature is strongly associated with hypoxia, with nine o

SUBMITTER: Haider S 

PROVIDER: S-EPMC4926297 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature