Synthesis of New Hydrated Geranylphenols and in Vitro Antifungal Activity against Botrytis cinerea.

ABSTRACT: Geranylated hydroquinones and other geranylated compounds isolated from Aplydium species have shown interesting biological activities. This fact has prompted a number of studies where geranylated phenol derivatives have been synthesized in order to assay their bioactivities. In this work, we report the synthesis of a series of new hydrated geranylphenols using two different synthetic approaches and their inhibitory effects on the mycelial growth of Botrytis cinerea. Five new hydrated geranylphenols were obtained by direct coupling reaction between geraniol and phenol in dioxane/water and using BF₃·Et₂O as the catalyst or by the reaction of a geranylated phenol with BF₃·Et₂O. Two new geranylated quinones were also obtained. The synthesis and structural elucidation of all new compounds is pr

SUBMITTER: Soto M 

PROVIDER: S-EPMC4926374 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature