Ontology highlight
ABSTRACT:
SUBMITTER: Liu JJ
PROVIDER: S-EPMC4926382 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20160531 6
MicroRNAs (miRNAs) have been identified as key players in cardiomyocyte hypertrophy, which is associated with significant risks of heart failure. However, many microRNAs are still not recognized for their functions in pathophysiological processes. In this study, we evaluated effects of miR-218 in cardiomyocyte hypertrophy using both in vitro and in vivo models. We found that miR-218 was evidently downregulated in a transverse aortic constriction (TAC) mouse model. Overexpression of miR-218 is su ...[more]