Antibacterial Activity of Juglone against Staphylococcus aureus: From Apparent to Proteomic.

ABSTRACT: The proportion of foodborne disease caused by pathogenic microorganisms is rising worldwide, with staphylococcal food poisoning being one of the main causes of this increase. Juglone is a plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities. However, the specific mechanism underlying its antibacterial activity against Staphylococcus aureus remains unclear. To elucidate the mechanism underlying its antibacterial activity, isobaric tags for relative and absolute quantitation methods of quantitative proteomics were applied for analysis of the 53 proteins that were differentially expressed after treatment with juglone. Combined with verification experiments, such as detection of changes in DNA and RNA content and quantification of oxidative damage, our results

SUBMITTER: Wang J 

PROVIDER: S-EPMC4926497 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature