Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol.

ABSTRACT: Aberrant DNA methylation is a frequent epigenetic alteration in cancer cells that has emerged as a pivotal mechanism for tumorigenesis. Accordingly, novel therapies targeting the epigenome are being explored with the aim to restore normal DNA methylation patterns on oncogenes and tumor suppressor genes. A limited number of studies indicate that dietary compound resveratrol modulates DNA methylation of several cancer-related genes; however a complete view of changes in methylome by resveratrol has not been reported yet. In this study we performed a genome-wide survey of DNA methylation signatures in triple negative breast cancer cells exposed to resveratrol. Our data showed that resveratrol treatment for 24 h and 48 h decreased gene promoter hypermethylation and increased DNA hypomethylatio

SUBMITTER: Medina-Aguilar R 

PROVIDER: S-EPMC4927060 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature