Chemosensitivity, Cardiovascular Risk, and the Ventilatory Response to Exercise in COPD.

ABSTRACT:

Unlabelled

COPD is associated with elevated cardiovascular risk and a potentiated ventilatory response to exercise. Enhanced carotid chemoreceptor (CC) activity/sensitivity is present in other clinical conditions, has been shown to contribute to sympathetic vasoconstrictor outflow, and is predictive of mortality. CC activity/sensitivity, and the resulting functional significance, has not been well examined in COPD. We hypothesized that CC activity/sensitivity would be elevated in COPD, and related to increased pulse wave velocity (a marker of CV risk) and the ventilatory response to exercise.

Methods

30 COPD patients and 10 healthy age-matched controls were examined. Participants performed baseline cardiopulmonary exercise and pulmonary function testing. CC activity was late

SUBMITTER: Stickland MK 

PROVIDER: S-EPMC4927073 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature