Dense granule trafficking in Toxoplasma gondii requires a unique class 27 myosin and actin filaments.

ABSTRACT: The survival of Toxoplasma gondii within its host cell requires protein release from secretory vesicles, called dense granules, to maintain the parasite's intracellular replicative niche. Despite the importance of DGs, nothing is known about the mechanisms underlying their transport. In higher eukaryotes, secretory vesicles are transported to the plasma membrane by molecular motors moving on their respective cytoskeletal tracks (i.e., microtubules and actin). Because the organization of these cytoskeletal structures differs substantially in T. gondii, the molecular motor dependence of DG trafficking is far from certain. By imaging the motions of green fluorescent protein-tagged DGs in intracellular parasites with high temporal and spatial resolution, we show through a combination of molecu

SUBMITTER: Heaslip AT 

PROVIDER: S-EPMC4927281 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature