Novel genetic risk factors for asthma in African American children: Precision Medicine and the SAGE II Study.

ABSTRACT: Asthma, an inflammatory disorder of the airways, is the most common chronic disease of children worldwide. There are significant racial/ethnic disparities in asthma prevalence, morbidity, and mortality among US children. This trend is mirrored in obesity, which may share genetic and environmental risk factors with asthma. The majority of asthma biomedical research has been performed in populations of European decent. We sought to identify genetic risk factors for asthma in African American children. We also assessed the generalizability of genetic variants associated with asthma in European and Asian populations to African American children. Our study population consisted of 1227 (812 asthma cases, 415 controls) African American children with genome-wide single nucleotide polymorphism (SNP

SUBMITTER: White MJ 

PROVIDER: S-EPMC4927336 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature