Income and Markers of Immunological Cellular Aging.

ABSTRACT:

Objective

Socioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio. We hypothesized that participants with a lower income would have higher E/N ratios and lower CD4/CD8 ratios compared with participants with a higher income, and that these associations would be partially mediated by elevated cytomegalovirus (CMV) IgG antibody levels, a virus implicated in aging and clonal expansion of T cells.

Methods

Data were from 79 individuals who participated in the population-based Detroit Neighborhood Health

SUBMITTER: Aiello AE 

PROVIDER: S-EPMC4927391 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature