Protein Kinase Activity Decreases with Higher Braak Stages of Alzheimer's Disease Pathology.

ABSTRACT: Alzheimer's disease (AD) is characterized by a long pre-clinical phase (20-30 years), during which significant brain pathology manifests itself. Disease mechanisms associated with pathological hallmarks remain elusive. Most processes associated with AD pathogenesis, such as inflammation, synaptic dysfunction, and hyper-phosphorylation of tau are dependent on protein kinase activity. The objective of this study was to determine the involvement of protein kinases in AD pathogenesis. Protein kinase activity was determined in postmortem hippocampal brain tissue of 60 patients at various stages of AD and 40 non-demented controls (Braak stages 0-VI) using a peptide-based microarray platform. We observed an overall decrease of protein kinase activity that correlated with disease progression. The

SUBMITTER: Rosenberger AF 

PROVIDER: S-EPMC4927853 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature