Independent Replication of Published Germline Polymorphisms Associated with Urinary Bladder Cancer Prognosis and Treatment Response.

ABSTRACT:

Background

Many studies investigated the prognostic or predictive relevance of single nucleotide polymorphisms (SNPs) in biologically plausible genes in urinary bladder cancer (UBC) patients. Most published SNP associations have never been replicated in independent patient series.

Objective

To independently replicate all previously reported associations between germline SNPs and disease prognosis or treatment response in UBC.

Methods

A Pubmed search was performed to identify studies published by July 1, 2014 reporting on germline SNP associations with UBC prognosis or treatment response. For the replication series, consisting of 1,284 non-muscle-invasive bladder cancer (NMIBC) and 275 muscle-invasive or metastatic bladder cancer (MIBC) patients recruited through the N

SUBMITTER: Grotenhuis AJ 

PROVIDER: S-EPMC4927992 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature