Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.

ABSTRACT:

Importance

Advances have been made in identifying genetic susceptibility loci for autoimmune diseases, but evidence is needed regarding their association with prognosis and treatment response.

Objective

To assess whether specific HLA-DRB1 haplotypes associated with rheumatoid arthritis (RA) susceptibility are also associated with radiological severity, mortality, and response to tumor necrosis factor (TNF) inhibitor drugs.

Design, setting, and participants

The Norfolk Arthritis Register (NOAR; 1691 patients and 2811 radiographs; recruitment: 1989-2008; 2008 as final follow-up) was used as a discovery cohort and the Early Rheumatoid Arthritis Study (421 patients and 3758 radiographs; recruitment: 1986-1999; 2005 as final follow-up) as an independent replication cohort

SUBMITTER: Viatte S 

PROVIDER: S-EPMC4928097 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature