KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily.

ABSTRACT:

Background

The association between aberrant signal processing by protein kinases and human diseases such as cancer was established long time ago. However, understanding the link between sequence variants in the protein kinase superfamily and the mechanistic complex traits at the molecular level remains challenging: cells tolerate most genomic alterations and only a minor fraction disrupt molecular function sufficiently and drive disease.

Results

KinMutRF is a novel random-forest method to automatically identify pathogenic variants in human kinases. Twenty six decision trees implemented as a random forest ponder a battery of features that characterize the variants: a) at the gene level, including membership to a Kinbase group and Gene Ontology terms; b) at the PFAM domain lev

SUBMITTER: Pons T 

PROVIDER: S-EPMC4928150 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature