Initial investigation of three selective and potent small molecule oxytocin receptor PET ligands in New World monkeys.

ABSTRACT: The neuropeptide oxytocin is part of a neuroendocrine system that has physiological effects ranging from ensuring uterine myometrial contractions at parturition and post-partum mammary gland milk ejection to the modulation of neural control of social relationships. This initial study was performed to investigate the potential use of positron emission tomography (PET) for localizing oxytocin receptors in two New World primates. Three biomarkers for PET (1-3) that are known to have high affinity and selectivity for the human oxytocin receptor were investigated in the common marmoset (Callithrix jacchus) via PET imaging. Brain penetration, and uptake in the salivary gland area were both observed with biomarkers 2 and 3. No brain penetration was observed with 1, but uptake was observed more sp

SUBMITTER: Smith AL 

PROVIDER: S-EPMC4928571 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature