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Exercise Increases and Browns Muscle Lipid in High-Fat Diet-Fed Mice.

ABSTRACT: Muscle lipid increases with high-fat feeding and diabetes. In trained athletes, increased muscle lipid is not associated with insulin resistance, a phenomenon known as the athlete's paradox. To understand if exercise altered the phenotype of muscle lipid, female C57BL/6 mice fed CTL or high-fat diet (HFD for 6 or 18?weeks) were further divided into sedentary or exercising groups (CTL-E or HFD-E) with voluntary access to running wheels for the last 6?weeks of experiments, running 6?h/night. Diet did not affect running time or distance. HFD mice weighed more than CTL after 18?weeks (p?

SUBMITTER: Morton TL 

PROVIDER: S-EPMC4928595 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Exercise Increases and Browns Muscle Lipid in High-Fat Diet-Fed Mice.

Morton Tiffany L TL   Galior Kornelia K   McGrath Cody C   Wu Xin X   Uzer Gunes G   Uzer Guniz Bas GB   Sen Buer B   Xie Zhihui Z   Tyson David D   Rubin Janet J   Styner Maya M  

Frontiers in endocrinology 20160630

Muscle lipid increases with high-fat feeding and diabetes. In trained athletes, increased muscle lipid is not associated with insulin resistance, a phenomenon known as the athlete's paradox. To understand if exercise altered the phenotype of muscle lipid, female C57BL/6 mice fed CTL or high-fat diet (HFD for 6 or 18 weeks) were further divided into sedentary or exercising groups (CTL-E or HFD-E) with voluntary access to running wheels for the last 6 weeks of experiments, running 6 h/night. Diet  ...[more]

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