Association Between Long-term Oral Contraceptive Use and Risk of Crohn's Disease Complications in a Nationwide Study.

ABSTRACT:

Background & aims

Use of exogenous hormones, in the form of oral contraceptives (OCs), has been linked consistently to risk of Crohn's disease (CD). Nonetheless, it is not clear how OCs might contribute to the progression of CD.

Methods

We conducted a prospective study of female patients with CD (age, 16-51 y), identified from the inpatient and outpatient care components of the Swedish National Patient Register from January 2002 through December 2013. Information on current OC use was obtained from the Prescribed Drug Register starting in July of 2005 and updated until December of 2013. Primary outcomes were defined as first CD-related surgery and first steroid prescription. We used Cox proportional hazard modeling with time-varying covariates to estimate multivariable-adjus

SUBMITTER: Khalili H 

PROVIDER: S-EPMC4928680 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature