Circulating MicroRNAs: Association with Lung Function in Asthma.

ABSTRACT:

Background

MicroRNAs are key transcriptional and network regulators previously associated with asthma susceptibility. However, their role in relation to asthma severity has not been delineated.

Objective

We hypothesized that circulating microRNAs could serve as biomarkers of changes in lung function in asthma patients.

Methods

We isolated microRNAs from serum samples obtained at randomization for 160 participants of the Childhood Asthma Management Program. Using a TaqMan microRNA array containing 754 microRNA primers, we tested for the presence of known asthma microRNAs, and assessed the association of the individual microRNAs with lung function as measured by FEV1/FVC, FEV1% and FVC%. We further tested the subset of FEV1/FVC microRNAs for sex-specific and lung develo

SUBMITTER: Kho AT 

PROVIDER: S-EPMC4928864 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature