Evolutionary and Topological Properties of Genes and Community Structures in Human Gene Regulatory Networks.

ABSTRACT: The diverse, specialized genes present in today's lifeforms evolved from a common core of ancient, elementary genes. However, these genes did not evolve individually: gene expression is controlled by a complex network of interactions, and alterations in one gene may drive reciprocal changes in its proteins' binding partners. Like many complex networks, these gene regulatory networks (GRNs) are composed of communities, or clusters of genes with relatively high connectivity. A deep understanding of the relationship between the evolutionary history of single genes and the topological properties of the underlying GRN is integral to evolutionary genetics. Here, we show that the topological properties of an acute myeloid leukemia GRN and a general human GRN are strongly coupled with its genes' e

SUBMITTER: Szedlak A 

PROVIDER: S-EPMC4928929 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature