In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model.

ABSTRACT: The sharing of circulation between two animals using a surgical procedure known as parabiosis has created a wealth of information towards our understanding of physiology, most recently in the neuroscience arena. The systemic milieu is a complex reservoir of tissues, immune cells, and circulating molecules that is surprisingly not well understood in terms of its communication across organ systems. While the model has been used to probe complex physiological questions for many years, critical parameters of recovery and exchange kinetics remain incompletely characterized, limiting the ability to design experiments and interpret results for complex questions. Here we provide evidence that mice joined by parabiosis gradually recover much physiology relevant to the study of brain function. Speci

SUBMITTER: Castellano JM 

PROVIDER: S-EPMC4929497 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature