Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore.

ABSTRACT:

Background

Enhanced expression of the purinergic P2X7 receptor (P2X7R) occurs in several neuroinflammatory conditions where increased microglial activation is a co-existing feature. P2X7 receptors can function either as a cation channel or, upon continued stimulation, a large pore. P2X7R-over-expression alone is sufficient to drive microglial activation and proliferation in a process that is P2X7R pore dependent, although the biological signaling pathway through which this occurs remains unclear. Once activated, microglia are known to release a number of bioactive substances that include the proinflammatory cytokine interleukin-1β (IL-1β). Previous studies have linked P2X7R stimulation to the processing and release of IL-1β, but whether the channel or pore state of P2X7R is predomi

SUBMITTER: Monif M 

PROVIDER: S-EPMC4929731 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature