Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis.

ABSTRACT:

Background

Upper respiratory infections (URI) and their complications are a major healthcare burden for pediatric populations. Although the microbiology of the nasopharynx is an important determinant of the complications of URI, little is known of the nasopharyngeal (NP) microbiota of children, the factors that affect its composition, and its precise relationship with URI.

Results

Healthy children (n = 47) aged 49-84 months from a prospective cohort study based in Wisconsin, USA, were examined. Demographic and clinical data and NP swab samples were obtained from participants upon entry to the study. All NP samples were profiled for bacterial microbiota using a phylogenetic microarray, and these data were related to demographic characteristics and upper respiratory health out

SUBMITTER: Santee CA 

PROVIDER: S-EPMC4929776 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature