Benefit of Delayed Fertility Therapy With Preconception Weight Loss Over Immediate Therapy in Obese Women With PCOS.

ABSTRACT:

Context

In overweight/obese women with polycystic ovary syndrome (PCOS), the relative benefit of delaying infertility treatment to lose weight vs seeking immediate treatment is unknown.

Objective

We compared the results of two, multicenter, concurrent clinical trials treating infertility in women with PCOS.

Design, setting, and participants

This was a secondary analysis of two randomized trials conducted at academic health centers studying women 18-40 years of age who were overweight/obese and infertile with PCOS.

Intervention

We compared immediate treatment with clomiphene from the Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial (N = 187) to delayed treatment with clomiphene after preconception treatment with continuous oral contraceptives, lifestyl

SUBMITTER: Legro RS 

PROVIDER: S-EPMC4929837 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature