Decreased Circulating Levels of Spexin in Obese Children.

ABSTRACT:

Context

Spexin is a novel peptide that is implicated in obesity and related energy homeostasis in animals and adult humans. Little is known about its role in children.

Objective

The aim of the current study was to determine the potential role of Spexin in obese children and explore its relationships with various cardiometabolic risk factors.

Design and participants

This was a cross-sectional study composed of 69 children (51 obese and 18 normal weight; age 15.3 ± 0.26 y).

Outcome measures

Spexin was measured using a specific enzyme-linked immunosorbent assay. Leptin, total and high-molecular-weight adiponectin, IL-6, high-sensitivity C-reactive protein, glucose, and insulin were also measured. Mann-Whitney U test, Pearson and Spearman rank correlations, logisti

SUBMITTER: Kumar S 

PROVIDER: S-EPMC4929838 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature