Absence of systemic oxidative stress and increased CSF prostaglandin F2α in progressive MS.

ABSTRACT:

Objective

We aimed to investigate the role of oxidative stress in the progression of multiple sclerosis (MS).

Methods

We determined by liquid chromatography-tandem mass spectrometry nonenzymatic (F2-isoprostanes) and enzymatic oxidation products of arachidonic acid (prostaglandin F2α [PGF2α]) in plasma and CSF of 45 controls (other neurologic disease [OND] with no signs of inflammation) and 62 patients with MS. Oxidation products were correlated with disease severity and validated biomarkers of inflammation (chemokine ligand 13; matrix metalloproteinase-9; osteopontin) and axonal damage (neurofilament light protein).

Results

Compared with OND controls, plasma concentrations of F2-isoprostanes and PGF2α were significantly lower in patients with progressive disease, and

SUBMITTER: Lam MA 

PROVIDER: S-EPMC4929888 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature