A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set.

ABSTRACT: The Brazilian population is considered to be highly admixed. The main contributing ancestral populations were European and African, with Amerindians contributing to a lesser extent. The aims of this study were to provide a resource for determining and quantifying individual continental ancestry using the smallest number of SNPs possible, thus allowing for a cost- and time-efficient strategy for genomic ancestry determination. We identified and validated a minimum set of 192 ancestry informative markers (AIMs) for the genetic ancestry determination of Brazilian populations. These markers were selected on the basis of their distribution throughout the human genome, and their capacity of being genotyped on widely available commercial platforms. We analyzed genotyping data from 6487 individual

SUBMITTER: Santos HC 

PROVIDER: S-EPMC4930091 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature