A general approach for combining diverse rare variant association tests provides improved robustness across a wider range of genetic architectures.

ABSTRACT: The widespread availability of genome sequencing data made possible by way of next-generation technologies has yielded a flood of different gene-based rare variant association tests. Most of these tests have been published because they have superior power for particular genetic architectures. However, for applied researchers it is challenging to know which test to choose in practice when little is known a priori about genetic architecture. Recently, tests have been proposed which combine two particular individual tests (one burden and one variance components) to minimize power loss while improving robustness to a wider range of genetic architectures. In our analysis we propose an expansion of these approaches, yielding a general method that works for combining any number of individual test

SUBMITTER: Greco B 

PROVIDER: S-EPMC4930097 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature