Lateral prefrontal model-based signatures are reduced in healthy individuals with high trait impulsivity.

ABSTRACT: High impulsivity is an important risk factor for addiction with evidence from endophenotype studies. In addiction, behavioral control is shifted toward the habitual end. Habitual control can be described by retrospective updating of reward expectations in 'model-free' temporal-difference algorithms. Goal-directed control relies on the prospective consideration of actions and their outcomes, which can be captured by forward-planning 'model-based' algorithms. So far, no studies have examined behavioral and neural signatures of model-free and model-based control in healthy high-impulsive individuals. Fifty healthy participants were drawn from the upper and lower ends of 452 individuals, completing the Barratt Impulsiveness Scale. All participants performed a sequential decision-making task du

SUBMITTER: Deserno L 

PROVIDER: S-EPMC4930122 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature