Right external globus pallidus changes are associated with altered causal awareness in youth with depression.

ABSTRACT: Cognitive impairment is a functionally disabling feature of depression contributing to maladaptive decision-making, a loss of behavioral control and an increased disease burden. The ability to calculate the causal efficacy of ones actions in achieving specific goals is critical to normal decision-making and, in this study, we combined voxel-based morphometry (VBM), shape analysis and diffusion tensor tractography to investigate the relationship between cortical-basal ganglia structural integrity and such causal awareness in 43 young subjects with depression and 21 demographically similar healthy controls. Volumetric analysis determined a relationship between right pallidal size and sensitivity to the causal status of specific actions. More specifically, shape analysis identified dorsolater

SUBMITTER: Griffiths KR 

PROVIDER: S-EPMC4930125 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature