Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon.

ABSTRACT:

Background/aims

Neurotensin is a gut-brain peptide with both inhibitory and excitatory actions on the colonic musculature; our objective was to understand the implications of this for motor patterns occurring in the intact colon of the rat.

Methods

The effects of neurotensin with concentrations ranging from 0.1-100 nM were studied in the intact rat colon in vitro, by investigating spatio-temporal maps created from video recordings of colonic motility before and after neurotensin.

Results

Low concentration of neurotensin (0.1-1 nM) inhibited propagating long distance contractions and rhythmic propagating motor complexes; in its place a slow propagating rhythmic segmental motor pattern developed. The neurotensin receptor 1 antagonist SR-48692 prevented the development o

SUBMITTER: Li H 

PROVIDER: S-EPMC4930308 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature